With no known precedent, Children’s Hospital of Philadelphia (CHOP) pursued a vision to develop a new pediatric patient care unit: one that would meet the requirements and licensure of an acute care unit, and would provide a safe and supportive environment for patients with a comorbid developmental, behavioral, or psychiatric diagnosis. A multidisciplinary team led by ZGF worked together to envision, plan, and design an environment that would support a new model of care for this unique patient population that was previously treated in a general medical surgical unit. The Medical Behavioral Unit (MBU) is a remodel of an existing unit on CHOP’s campus in Philadelphia. It provides a supportive environment with programmed spaces not typically found in an acute care unit, including places for creative activities, relaxation, and meditation rooms where patients can self-soothe.